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KMID : 0363420170310020034
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Journal of Korean Oriental Pediatrics
2017 Volume.31 No. 2 p.34 ~ p.47
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Effects of Forsythiae Fructus, Ulmi Cortex and JwaGwiEum in Allergic Rhinitis Induced by Ovalbumin in Mice
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Kim Bit-Na-Rae
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Abstract
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Objectives: In the past, studies have been shown that Forsythiae Fructus (FF), Ulmi Cortex (UC) and JwaGwiEum (JGE) are effective in treating allergic reactions. However, no report shows the difference in effects of FF, UC and JGE in
allergic rhinitis (AR). Therefore, the purpose of this study was to differentiate the effects of FF, UC and JGE in AR induced by ovalbumin (OVA) in mice.
Methods: From this experiment, the effects of FF, UC and JGE were several ? changes in body weight, hematologic
changes such as WBC, RBC, Hb and PLT counts, immunological changes such as levels of histamine, IgE, IL-4 and expressions of iNOS & COX-2 mRNA. Moreover, histological change of nasal mucosa was also investigated.
Results: FF administration group and JGE administration group significantly inhibited level of IgE compared to the control group. Also, FF administration group, UC administration group and JGE administration group inhibited IL-4 and expressions of iNOS & COX-2 mRNA. In histological assessment, FF administration group, UC administration group and JGE administration group showed reduced amount of subepithelial edema, desquamated mucosa and hyperplasia of basement membrane from OVA.
Conclusions: In conclusion, these data suggest that FF, UC and JGE can treat the symptoms of AR
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KEYWORD
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Allergic rhinitis, Forsythiae fructus, Ulmi cortex, Jwagwieum, Ovalbumin (OVA)
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